Prolotherapy and Prolozone Therapy. Injection of tissue proliferant (like ozone, dextrose, etc.) inside the joint and around the joint reduces pain, inflammation and its highly effective, non-surgical medical treatment for resolving ligament and tendon injuries. “Prolo” is short form of proliferation, because the treatment causes the proliferation of new connective tissue and recruit new healing cells.
The term, “Orthobiologics” is a combination of Ortho (referring to the bones, joints, muscles, and tendons) and biologics, which in this context refers to substances that are naturally derived and can heal orthopedic tissues. Common Orthobiologics include platelet-rich plasma, bone marrow concentrate, certain fat grafts, and birth tissues. These substances are either autologous or allogeneic and they can help bones, joints, muscles, or tendons heal if they are precisely injected or placed.